The Evil has a new enemy. The Justice has a new Weapon. And the world has a new hero. An assassin named Al Simmons is double-crossed and murdered by his evil boss Jason Wynn. Al makes a deal with the devil and returns to earth as Spawn to see his wife. He is ordered by the devil's minion, The Clown, to kill Wynn. Wynn has made a deal with the clown too and is suppose to destroy the world with a deadly virus that will help start Armageddon and allow Hell to attack Heaven. Spawn must choose between Good & Evil.

En el pequeño pueblo costero de Darkness Falls existe una terrible leyenda acerca de una mujer a la que llamaban "El hada de los dientes". Hace 150 años vivía Matilda Dixon, una simpática ancianita que cuidaba a niños que a cambio de tartas y galletas, le entregaban sus dientes de leche. Pero un día es injustamente acusada de un crimen, y es brutalmente asesinada por los habitantes enloquecidos por la ira.